[Articles] Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association study
January 19, 2016
- The Lancet 387, 10014 (2016)
Author: Isabelle Cleynen, Gabrielle Boucher, Luke Jostins, L Philip Schumm, Sebastian Zeissig, Tariq Ahmad, Vibeke Andersen, Jane M Andrews, Vito Annese, Stephan Brand, Steven R Brant, Judy H Cho, Mark J Daly, Marla Dubinsky, Richard H Duerr, Lynnette R Ferguson, Andre Franke, Richard B Gearry, Philippe Goyette, Hakon Hakonarson, Jonas Halfvarson, Johannes R Hov, Hailang Huang, Nicholas A Kennedy, Limas Kupcinskas, Ian C Lawrance, James C Lee, Jack Satsangi, Stephan Schreiber, Emilie Théâtre, Andrea E van der Meulen-de Jong, Rinse K Weersma, David C Wilson, International Inflammatory Bowel Disease Genetics Consortium, Miles Parkes, Severine Vermeire, John D Rioux, John Mansfield, Mark S Silverberg, Graham Radford-Smith, Dermot P B McGovern, Jeffrey C Barrett, Charlie W Lees
Our data support a continuum of disorders within inflammatory bowel disease, much better explained by three groups (ileal Crohn’s disease, colonic Crohn’s disease, and ulcerative colitis) than by Crohn’s disease and ulcerative colitis as currently defined. Disease location is an intrinsic aspect of a patient’s disease, in part genetically determined, and the major driver to changes in disease behaviour over time.