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[Comment] Lithium therapy in bipolar disorder: a balancing act?

Quite reasonably, patients with bipolar disorder want treatment that provides sustained relief from their illness without incurring serious side-effects. Functionally, this translates to the resumption of purpose and enjoyment. But of the numerous drugs available for the management of bipolar disorder, only lithium seems to truly stabilise mood.1 Its status as an effective prophylactic agent was convincingly reinstated by the findings of the randomised, open-label BALANCE trial,2 which corroborated empirical knowledge.