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[Comment] Long working hours: an avoidable cause of stroke?

William Osler, in an article about atherosclerosis published 100 years ago, wrote that the main cause of myocardial infarction was “wear and tear of life”.1 Although we now have more detailed theories regarding the causal mechanisms, there is still some kinship between modern studies of work-related determinants of cardiovascular diseases and Osler’s broad approach to the cause of disease.2