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[Comment] Open questions for non-infarct-related arteries in STEMI

Few questions in cardiology have received more disparate answers and caused such sudden reversals in official guidelines as that of the best treatment of clinically significant lesions in non-infarct-related arteries, which affect more than half of patients with ST-elevation myocardial infarction (STEMI). Findings of large meta-analyses show that simultaneous multivessel percutaneous coronary intervention (PCI) has a worse outcome than does PCI of the infarct-related artery alone.1,2 Staged PCI for treatment of clinically significant lesions in non-infarct-related arteries is still recommended in current European Society of Cardiology guidelines for STEMI, published in 2012.

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