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[Comment] Prolonged antiplatelet therapy after drug-eluting stents

After use of intracoronary drug-eluting stents, a regimen of two antiplatelet agents (ie, dual antiplatelet therapy [DAPT]) is necessary to prevent stent thrombosis, a complication associated with myocardial infarction and death. Conventional DAPT includes aspirin and a P2Y12 platelet receptor inhibitor such as clopidogrel, prasugrel, or ticagrelor.1 The optimum duration of DAPT is the subject of much debate; prevention of stent thrombosis has to be balanced against the elevated risk of bleeding associated with two agents.

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