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[Correspondence] The GAS trial – Authors’ reply

Beverley Orser and colleagues correctly point out the limitations of our study,1 which were also highlighted in our discussion and the accompanying Comment.2 We agree that a more extensive follow-up of the children aged 5 years is essential, that indeed is our primary outcome. We also agree with Markus Weiss and colleagues that there are many other factors besides possible anaesthetic neurotoxic effects that might influence the short-term and long-term outcome of anaesthesia and surgery in infants.