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Acellular pertussis vaccine effectiveness for children during the 2009–2010 pertussis epidemic in Queensland

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In Queensland, 2009 and 2010 were epidemic years for pertussis. New patterns of disease emerged, with particularly high rates of pertussis notification for those aged 6 – < 12 years despite high primary course and booster vaccine coverage for more than a decade. A similar disease pattern was observed in California.1 Evidence from Qld,2 California36 and Oregon7 indicates that changing from whole-cell to acellular pertussis vaccine in the late 1990s8,9 contributed to recent pertussis epidemiology. In Qld and Northern California, the highest notification rates during 2010 occurred in the first birth cohorts to receive acellular pertussis vaccine. North American studies describe rapid waning of protection following a five-dose course of acellular pertussis vaccine.4,5,10 Data from Qld2 and Oregon7