[Articles] 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial
March 5, 2015
- The Lancet 385, 9983 (2015)
Author: Christoph C Lees, Neil Marlow, Aleid van Wassenaer-Leemhuis, Birgit Arabin, Caterina M Bilardo, Christoph Brezinka, Sandra Calvert, Jan B Derks, Anke Diemert, Johannes J Duvekot, Enrico Ferrazzi, Tiziana Frusca, Wessel Ganzevoort, Kurt Hecher, Pasquale Martinelli, Eva Ostermayer, Aris T Papageorghiou, Dietmar Schlembach, K T M Schneider, Baskaran Thilaganathan, Tullia Todros, Adriana Valcamonico, Gerard H A Visser, Hans Wolf, TRUFFLE study group
Although the difference in the proportion of infants surviving without neuroimpairment was non-significant at the primary endpoint, timing of delivery based on the study protocol using late changes in the DV waveform might produce an improvement in developmental outcomes at 2 years of age.