[Articles] Causes and incidence of community-acquired serious infections among young children in south Asia (ANISA): an observational cohort study
July 23, 2018
- The Lancet 392, 10142 (2018)
Author: Samir K Saha, Stephanie J Schrag, Shams El Arifeen, Luke C Mullany, Mohammad Shahidul Islam, Nong Shang, Shamim A Qazi, Anita K M Zaidi, Zulfiqar A Bhutta, Anuradha Bose, Pinaki Panigrahi, Sajid B Soofi, Nicholas E Connor, Dipak K Mitra, Rita Isaac, Jonas M Winchell, Melissa L Arvay, Maksuda Islam, Yasir Shafiq, Imran Nisar, Benazir Baloch, Furqan Kabir, Murtaza Ali, Maureen H Diaz, Radhanath Satpathy, Pritish Nanda, Bijaya K Padhi, Sailajanandan Parida, Aneeta Hotwani, M Hasanuzzaman, Sheraz Ahmed, Mohammad Belal Hossain, Shabina Ariff, Imran Ahmed, Syed Mamun Ibne Moin, Arif Mahmud, Jessica L Waller, Iftekhar Rafiqullah, Mohammad A Quaiyum, Nazma Begum, Veeraraghavan Balaji, Jasmin Halen, A S M Nawshad Uddin Ahmed, Martin W Weber, Davidson H Hamer, Patricia L Hibberd, Qazi Sadeq-ur Rahman, Venkat Raghava Mogan, Tanvir Hossain, Lesley McGee, Shalini Anandan, Anran Liu, Kalpana Panigrahi, Asha Mary Abraham, Abdullah H Baqui
Non-attribution of a cause in a high proportion of patients suggests that a substantial proportion of pSBI episodes might not have been due to infection. The predominance of bacterial causes among babies who died, however, indicates that appropriate prevention measures and management could substantially affect neonatal mortality. Susceptibility of bacterial isolates to first-line antibiotics emphasises the need for prudent and limited use of newer-generation antibiotics. Furthermore, the predominance of atypical bacteria we found and high incidence of respiratory syncytial virus indicated that changes in management strategies for treatment and prevention are needed.