[Articles] Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study
October 4, 2016
- The Lancet 388, 10051 (2016)
Author: Jie Liu, James A Platts-Mills, Jane Juma, Furqan Kabir, Joseph Nkeze, Catherine Okoi, Darwin J Operario, Jashim Uddin, Shahnawaz Ahmed, Pedro L Alonso, Martin Antonio, Stephen M Becker, William C Blackwelder, Robert F Breiman, Abu S G Faruque, Barry Fields, Jean Gratz, Rashidul Haque, Anowar Hossain, M Jahangir Hossain, Sheikh Jarju, Farah Qamar, Najeeha Talat Iqbal, Brenda Kwambana, Inacio Mandomando, Timothy L McMurry, Caroline Ochieng, John B Ochieng, Melvin Ochieng, Clayton Onyango, Sandra Panchalingam, Adil Kalam, Fatima Aziz, Shahida Qureshi, Thandavarayan Ramamurthy, James H Roberts, Debasish Saha, Samba O Sow, Suzanne E Stroup, Dipika Sur, Boubou Tamboura, Mami Taniuchi, Sharon M Tennant, Deanna Toema, Yukun Wu, Anita Zaidi, James P Nataro, Karen L Kotloff, Myron M Levine, Eric R Houpt
A quantitative molecular diagnostic approach improved population-level and case-level characterisation of the causes of diarrhoea and indicated a high burden of disease associated with six pathogens, for which targeted treatment should be prioritised.