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[Case Report Comment] Clinical overlap in proximal artery stenosis: two disorders or one?

ANCA-associated vasculitis comprises three conditions that share overlapping clinical and serological features and are characterised by necrotising inflammation of small vessel walls: granulomatosis with polyangiitis (Wegener’s granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome). Although the cause is unknown, ANCA antibodies, cytokine-primed neutrophils, and B lymphocytes are recognised to play an important part in disease pathogenesis.