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[Case Report Comment] Cobalamin C deficiency-associated thrombotic microangiopathy: uncommon or unrecognised?

When I first cared for patients with microangiopathic haemolytic anaemia and thrombocytopenia 45 years ago, knowledge was limited and treatments were ineffective. These syndromes have since been defined as thrombotic microangiopathy and multiple causes and effective treatments have been described.1