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[Case Report Comment] Hepatitis C viraemia after apparent spontaneous clearance

Vertical transmission of hepatitis C virus (HCV) from infected mothers to their infants occurs in less than 10% of cases, but is the main route of infection in children today following effective screening of blood and blood products.1 Diagnosis is made by detection of HCV RNA in blood at 4–12 weeks of age or at 12 months. Spontaneous seroconversion in this group, defined as absence of detectable HCV RNA on two occasions 6 months apart, is less than 10% in the UK, and to date has been considered to be permanent.