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[Clinical Picture] Platelet interaction with erythrocytes and propensity to aggregation in essential thrombocythaemia

3 years after diagnosis with essential thrombocythaemia (JAK2 Val617Phe mutation) in January, 2011, a healthy 26-year-old white woman was referred to the Applied Morphology Research Centre at the University of Pretoria for an ultrastructural blood analysis because of a platelet count of 1240 × 109 cells per L (normal range 150–300 × 109 cells per L). Essential thrombocythaemia is a myeloproliferative disorder characterised by hyperplasia of megakaryocytes in the bone marrow and thrombocytosis. The JAK2 Val617Phe mutation is present in about 50% of people with essential thrombocythaemia and leads to megakaryocyte hyperplasia and consequent thrombocytosis.