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[Comment] 4CMenB vaccine effectiveness: reasons for optimism

Preventing invasive meningococcal disease caused by the bacterial pathogen Neisseria meningitidis is of crucial public health importance in view of the sudden onset of symptoms, rapid progression to serious disease, and high risk of mortality even among previously healthy individuals.1,2 The burden of invasive meningococcal disease has been reduced in many parts of the world through extensive public health efforts—most notably the introduction of conjugate group C vaccines in the UK in 1999,3 and conjugate group A vaccines in the African meningitis belt beginning in 2010.