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[Comment] A quarter-dose quadpill for initial treatment of hypertension

The immediate goal of antihypertensive therapy is the prompt achievement of target blood pressure without adverse effects on quality of life. The efficacy, tolerability, and safety of available pharmacological agents makes attainment of these goals possible in most patients. Nevertheless, undertreatment of hypertension results in the continued occurrence of many preventable and potentially negative outcomes for patients worldwide. In the National Health and Nutrition Examination Survey (NHANES) reported in 2008,1 estimates of age-standardised cardiovascular mortality directly attributable to uncontrolled blood pressure in the USA were 260 cases per 100 000 women and 290 cases per 100 000 men.