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[Comment] Anacetrapib in familial hypercholesterolaemia: pros and cons

Cholesterol ester transfer protein (CETP) promotes transfer of cholesterol esters from HDL, in exchange for triglycerides from proatherogenic apolipoprotein B-containing lipoproteins. Genetic deficiency or pharmacological inhibition of CETP is associated with cholesterol enrichment of HDL and reduction of LDL cholesterol (LDL-C) concentrations.