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[Comment] Are we ready for targeted therapy for IgA nephropathy?

Almost 50 years have passed since the initial description of IgA nephropathy by Berger and Hinglais.1 IgA nephropathy is the most common chronic glomerulonephritis in the world.2 A renal biopsy is required for diagnosis but not regularly performed early in the course of the disease in some regions.3 Clearly, many people with this disease go undiagnosed, as shown by marked differences in population-based incidences for European and North American cohorts.4 Variation exists even within a single country, as evidenced by 70% more kidney biopsies being performed in the Tayside region of Scotland compared with Greater Glasgow.