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[Comment] BASKET-SMALL 2: advancing DCB beyond in-stent restenosis

Drug-coated balloons (DCB) were first used as a new therapeutic option in the treatment of in-stent restenosis, with proven inhibition of restenosis in clinical studies.1–3 DCB have received a class 1 indication in the 2014 European Society of Cardiology guidelines4 for the treatment of both bare metal stent (BMS) and drug-eluting stent (DES) in-stent restenosis. The next question is whether DCB are effective in de-novo coronary lesions, specifically in small coronary vessels.