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[Comment] Biodegradable polymer drug-eluting stents: non-inferiority waiting for superiority?

Drug-eluting stents are the most widely used interventional treatment for obstructive coronary artery disease. In early and later generation drug-eluting stents, permanent polymers were used to help prolong drug release, which is essential for the prevention of restenosis. However, some permanent polymer drug-eluting stents induce low-grade chronic inflammation, cell proliferation, and late restenosis.1 Moreover, prolonged drug exposure might lead to long-term endothelial dysfunction, promoting the development of atherosclerosis within the stented segment (neoatherosclerosis).