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[Comment] BMI and mortality: the limits of epidemiological evidence

Concurrent with the global increase in obesity,1 numerous studies and reviews have been published concerning associations of overweight and obesity with mortality. Their findings have prompted considerable public health debate. There is ongoing discussion as to whether cutoff points for body-mass index (BMI) categories should differ across regions or racial or ethnic groups.2 Additionally, studies differ in their assessment of the relation between BMI and mortality. In particular, BMI in the overweight category (BMI 25–<30 kg/m2) is not consistently associated with increased mortality.