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[Comment] Cartilage repair across germ layer origins

Treatment of articular cartilage injuries remains an important clinical problem; not only is the healing potential of these injuries constricted but also they constitute a major risk factor for development of osteoarthritis. Although various cartilage repair techniques have been developed, such as stimulation of endogenous regeneration and transplantation of autologous cells with chondrogenic potential, or tissue engineering approaches, no gold standard has been established.1 The most crucial issues in cell-based therapies are locating the most suitable cell source, deciding whether to apply cells with or without specific biomaterials and precultivation to secure ideal long-term outcomes, and minimising negative effects of tissue harvest.