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[Comment] Confronting the most challenging risk factor: non-adherence

Despite advances in cardiovascular therapies, coronary heart disease remains the leading cause of death in almost all countries. Two of the most remarkable recent treatments, percutaneous coronary intervention and the availability of proprotein convertase subtilisin/kexin type 9 inhibitor drugs, have revolutionised cardiology practice. Although life-saving and now essential therapies,1 whether they will be able to reduce the incidence and associated morbidity and mortality of coronary heart disease remains unlikely since the increase in prevalence of obesity and diabetes is raising the background level of cardiovascular risk.

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