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[Comment] Crohn’s disease: REACT to save the gut

Crohn’s disease affects roughly one in 300 adults in Europe and North America, with a rising global incidence.1 The disease usually develops from a predominantly inflammatory phenotype to penetrating and fibrostenotic intestinal complications. It carries substantial morbidity, with frequent hospital admissions, surgery, and need for corticosteroids and immunosuppressive drugs, and often results in poor quality of life and loss of workplace productivity. The cumulative incidence of abdominal surgery is 33% at 5 years, and 47% at 10 years.