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[Comment] De-intensified treatment in human papillomavirus-positive oropharyngeal cancer

The recognition of human papillomavirus (HPV) infection as a risk factor for the development of oropharyngeal squamous cell carcinoma was a substantial development in the field of head and neck oncology. HPV-positive oropharyngeal squamous cell carcinoma is widely considered a potential epidemic because of its rapidly increasing incidence.1 Furthermore, HPV-positive oropharyngeal squamous cell carcinoma is an entirely distinct disease entity from HPV-negative oropharyngeal squamous cell carcinoma.

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