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[Comment] Do we need more psoriasis therapies?

Until the year 2000, the only approved systemic treatments for psoriasis were methotrexate, ciclosporin, and acitretin. Oral methoxsalen with ultraviolet A phototherapy (PUVA) was another treatment option for severe psoriasis, and narrowband ultraviolet B was beginning to replace broadband ultraviolet B phototherapy. In Germany, oral fumarates were in use. However, although effective, those treatments had drawbacks. PUVA and ultraviolet B therapy necessitated office visits as frequently as three times weekly for months, and PUVA was associated with an increase in cutaneous malignancies.