[Comment] Do we need more psoriasis therapies?
Until the year 2000, the only approved systemic treatments for psoriasis were methotrexate, ciclosporin, and acitretin. Oral methoxsalen with ultraviolet A phototherapy (PUVA) was another treatment option for severe psoriasis, and narrowband ultraviolet B was beginning to replace broadband ultraviolet B phototherapy. In Germany, oral fumarates were in use. However, although effective, those treatments had drawbacks. PUVA and ultraviolet B therapy necessitated office visits as frequently as three times weekly for months, and PUVA was associated with an increase in cutaneous malignancies.