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[Comment] Effectiveness trials in asthma: time to SaLSA?

In your next clinical consultation, you may well find yourself asking the question “What is the likelihood that this treatment will benefit this patient at this time?” Evidence-based practice answers this question with data collected under ideal conditions from a double-blind, randomised, placebo-controlled trial (RCT). However, what evidence-based practice doesn’t tell us is that, when it comes to asthma and many other chronic diseases, only a minority of patients in your clinic would ever meet the eligibility criteria for these RCTs.