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[Comment] GEMS extend understanding of childhood diarrhoea

There is no doubt that the Global Enteric Multicenter Study (GEMS) has not only revolutionised understanding of diarrhoeal diseases in the young and vulnerable in some of the most disadvantaged areas of the world, but it has also altered the standard by which such studies are to be done going forward. Undoubtedly, for data such as these to be meaningful, controls and cases must be included.1,2 GEMS has also elucidated that the poorest of the poor might succumb to different pathogens at different rates in different parts of the world, which potentially affects prioritisation of interventions.