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[Comment] Haemopoietic stem-cell transplantation for multiple sclerosis: what next?

With approximately 2 million people affected worldwide, multiple sclerosis is among the most common chronic inflammatory diseases of the CNS, and despite major therapeutic advances in recent years, the disease is still insufficiently controlled in many patients.1 It is thought to be caused by autoimmunity. Therefore, resetting the adaptive immune system by eliminating aberrant self-reactive immune cells and inducing a more tolerant immunity is a potential treatment. Indeed, immunoablation and subsequent autologous haemopoietic stem-cell transplantation (aHSCT) have been investigated in patients with treatment-refractory multiple sclerosis.