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[Comment] Imaging of coronary inflammation for cardiovascular risk prediction

Inflammation plays an important part in the development of atherosclerosis and is a predictor of cardiovascular disease manifestation.1 Although circulating biomarkers of inflammation—eg, high sensitivity C-reactive protein—are associated with cardiovascular risk, they might not adequately reflect inflammatory activity in the coronary arteries at the individual patient level. Epicardial and perivascular adipose tissue—surrounding the heart and coronary arteries—secretes proinflammatory and anti-inflammatory cytokines and chemokines locally, and these tissues are associated with the extent and progression of coronary atherosclerosis and hard coronary events.