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[Comment] Improving management of neonatal infections

Infections causing sepsis, meningitis, or pneumonia contributed directly to around 0·6 million neonatal deaths worldwide in 2016,1 and indirectly to many more through pathways leading to preterm birth and neonatal encephalopathy. Despite this knowledge, understanding of the causes of neonatal infection, particularly in resource-poor settings, is limited. Treatment in these settings usually relies on the sensitive but non-specific clinical diagnosis of possible serious bacterial infection (pSBI),2 made by front-line health-care workers and defined according to set criteria.