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[Comment] Is intensity the solution for FMT in ulcerative colitis?

Inflammatory bowel diseases have been associated with a profound decrease in microbial diversity.1 Since the report by Turnbaugh and colleagues,2 in which the phenotype of a mouse was changed by faecal microbiota transfer (FMT), it became tempting to speculate that intestinal inflammation might be cured by this strategy. This idea has been proved by findings of a randomised trial in patients with Clostridium difficile colitis,3 whereby one FMT enema induced resolution of C difficile-associated diarrhoea in 81% (13 of 16) of patients.