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[Comment] Ketamine fails to prevent postoperative delirium

Postoperative delirium, an acute event of disordered cognition and attention, is often missed, creates anguish in hospital personnel and family members, and is associated with morbidity and mortality.1 The study by Michael Avidan and colleagues2 in The Lancet tests an intriguing hypothesis that ketamine, an anaesthetic and analgesic associated with hallucinations, might paradoxically reduce postoperative delirium. The findings of the study show that it does not.