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[Comment] Late clinical outcome of stent trials: a matter of life or death?

Millions of patients with obstructive coronary artery disease worldwide are treated with metallic stents each year. Since the first stent implantation in a human in 1986, stents have undergone substantial refinements that have involved numerous innovations and extensive clinical research.1 Over three decades, various problems were faced and solved or minimised. Among them were the frequent acute and sub-acute thrombotic occlusions of the very first stents, the recurrence of difficult-to-treat lesions within bare metal stents (typically within the first 6 months after implantation), and the late (1–12 months after implantation) and very late (>1 year after implantation) formation of thrombi in the first generation of drug-eluting stents.