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[Comment] Learning from the youngsters: ixekizumab in active ankylosing spondylitis

The COAST-V study published by Désirée van der Heijde and colleagues in The Lancet1 shows that ixekizumab, a monoclonal antibody that selectively targets interleukin (IL)-17A, is efficacious in patients with ankylosing spondylitis (also known as radiographic axial spondyloarthritis) who have previously been untreated with biological disease-modifying antirheumatic drugs (bDMARDs). Ixekizumab has already followed the other IL-17A antibody, secukinumab, in two other indications, psoriasis and psoriatic arthritis, and it seems likely that an approval for radiographic axial spondyloarthritis will follow on the basis of the evidence provided in this Article.