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[Comment] Lipoprotein(a): lodestar for future clinical trials

Lipoprotein(a) is an LDL-like particle with a covalently bound, unique glycoprotein called apolipoprotein(a).1 Concentrations of lipoprotein(a) in plasma are under tight genetic control, and in the population these amounts can be skewed positively in distribution, with one in four individuals inheriting levels that increase their lifetime risk of atherosclerotic cardiovascular disease by more than 50%.2 Interest in lipoprotein(a) has been rekindled by findings of large epidemiological3 and Mendelian randomisation4 studies that confirm the causal role of lipoprotein(a) in the development of atherosclerotic cardiovascular disease and calcific aortic valve disease.