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[Comment] Long-acting injectable ART: next revolution in HIV?

In the two decades since the arrival of triple antiretroviral therapy (ART),1,2 there have been multiple breakthroughs including new drugs in new classes, simplification from complex, restrictive regimens to single fixed-dose multiclass tablets, and major improvements in tolerability and toxicity.3–5 There is even an emerging re-examination of the triple therapy paradigm itself. Studies have shown that some dual-therapy combinations appear to confer the same success as conventional triple regimens, whether in individuals who are naive to ART or as a switch strategy.