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[Comment] Long-term albumin in cirrhosis: is it the ANSWER?

Ascites is the most frequent complication of cirrhosis and carries the worst prognosis.1 Although its development might be delayed by non-selective β-blockers,2 once ascites develops the patient progresses to refractory ascites, hyponatraemia, and renal dysfunction.3 This progression is due to worsening of portal pressure and worsening of the vasodilatory–hyperdynamic circulatory state, leading to progressive decrease in effective blood volume, cardiac dysfunction, and renal perfusion.4 Inflammation from overt or covert (bacterial translocation) infections is a major driver of progression.