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[Comment] Low-molecular-weight heparin for pregnancy complications

Pre-eclampsia, fetal growth restriction, placental abruption, and recurrent miscarriage are common placenta-mediated pregnancy complications. They have overlapping pathological features including deficient placentation, microvascular thrombosis, placental infarction, and an association with thrombophilia,1–3 implicating coagulation activation as a disease mechanism. Antithrombotic treatment has been shown to improve the outcome of antiphospholipid syndrome manifested as recurrent pregnancy loss, and low-dose aspirin provides a modest risk reduction in women with previous pre-eclampsia.