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[Comment] Network meta-analysis: a norm for comparative effectiveness?

In The Lancet, George Siontis and colleagues1 compare an array of possible percutaneous coronary interventions for treatment of in-stent restenosis. Most readers will recognise the hallmarks of a typical systematic review, with predefined eligibility criteria, a thorough search for studies, assessments of risk of bias for each study, consideration of the possibility of publication bias, and statistical combination (meta-analysis) of results across studies. Perhaps the most interesting aspect of their methods, however, is the use of the increasingly popular technique of network meta-analysis.