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[Comment] New pathways in the treatment for menopausal hot flushes

Within the next 25 years, an estimated 1 billion women worldwide will be older than 50 years, and therefore likely to be nearing menopause or postmenopausal.1 Hot flushes (vasomotor symptoms) are experienced by approximately 73% of postmenopausal women, and the associated sleep disturbances, fatigue, and decreased cognitive function lead to a reduction in their quality of life and an increased use of medical resources.2 A hypothalamic mechanism is well established in the understanding of hot flushes,3 but the pathways involved have been unclear, thus reducing therapeutic options.