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[Comment] Percutaneous coronary intervention: FAME is lasting

The landmark FAME study,1,2 which informs current guidelines for percutaneous coronary intervention (PCI) in patients with ischaemic heart disease,3,4 showed that case selection using physiological assessment of stenosis severity with measurement of fractional flow reserve (FFR) improves outcome compared with angiography-guided PCI. FFR is the ratio of the actual blood flow across a coronary stenosis during maximum vasodilation to the expected blood flow in the absence of a stenosis, and is measured with pressure sensors placed distal to the stenosis (panel).