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[Comment] Preventing postoperative delirium: all that glisters is not gold

Delirium is an important complication of surgery, affecting an estimated 30% of surgical patients in the intensive care unit (ICU).1 Postoperative delirium is distressing for patients and family members, and is associated with increased risk of further negative outcomes, including admission to institutions, dementia, and death.2 Unfortunately, many candidate pharmacological interventions to prevent postoperative delirium have failed.3 The cholinesterase inhibitor rivastigmine exemplifies the failures.