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[Comment] Procalcitonin-guided antibiotic stewardship from newborns to centennials

In 1993, Assicot and colleagues1 reported in The Lancet that procalcitonin was a marker of systemic infections in neonates and paediatric patients. In 2004, Christ-Crain and colleagues2 reported that procalcitonin guidance substantially reduced antibiotic use in adult patients presenting to the emergency room with lower respiratory tract infections, and in 2010, Bouadma and colleagues3 reported that a procalcitonin-guided strategy to treat suspected bacterial infections in non-surgical adult patients in intensive care units reduced antibiotic exposure and selective pressure with no apparent adverse outcome.