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[Comment] Progress in the treatment of juvenile dermatomyositis

Individuals affected by myositis, or muscle inflammation, have muscle weakness that leads to difficulties in standing up, climbing stairs, and lifting weight. In dermatomyositis, skin manifestations of the face and metacarpophalangeal joints are characteristic.1 Muscle inflammation leads to rapid and longlasting muscle cell death, reflected by a rise in circulating muscle enzymes (eg, creatine phosphokinase). Migration to and accumulation of immune cells in muscle, supported by the presence of circulating autoantibodies directed against nuclear components and constituents of muscle cells,2 has led to classification of dermatomyositis as an autoimmune disease, which has justified the use of drugs to control inflammation in a non-specific manner.