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[Comment] Recombinant human C1 esterase inhibitor for hereditary angio-oedema

Patients with the autosomal inheritable disease hereditary angio-oedema have recurrent swelling of subcutaneous and cutaneous tissues. The frequency of attacks varies enormously between individuals and can range from a few swellings per year to multiple attacks per week. In most cases, acute treatment is sufficient, but prophylactic treatment can reduce the burden of illness for severely impaired patients.1 Available treatments for hereditary angio-oedema prophylaxis comprise either plasma-derived C1 esterase inhibitor concentrates or attenuated androgens, such as danazol.