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[Comment] Reduce vascular risk to prevent dementia?

Dementia occurring in late life mainly consists of Alzheimer’s disease and is characterised by amyloid deposits, neurofibrillary tangles, and amyloid-containing neuritic plaques, along with neuron loss and gliosis. A substantial proportion of people with Alzheimer’s disease also have other pathological protein aggregates (eg, Lewy bodies and TDP-43), hippocampal sclerosis, and vascular brain injury that includes amyloid angiopathy, arteriolosclerosis, lacunar infarcts, microinfarcts, and haemorrhages.