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[Comment] Schizophrenia, primary negative symptoms, and soft outcomes in psychiatry

Eugen Bleuler, one of the founding fathers of psychiatry, who coined the term schizophrenia in 1908, considered so-called negative symptoms, such as lack of drive and motivation or social withdrawal, to be at the core of the disorder, while he regarded the more dramatic positive symptoms, such as delusions and hallucinations, as accessory.1 Unfortunately, antipsychotics have been shown effective for positive symptoms, but they have limited efficacy for negative symptoms, which remain an unresolved problem.