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[Comment] Seizures in tuberous sclerosis complex: hitting the target

Tuberous sclerosis complex is an autosomal dominant disorder of cellular proliferation and differentiation due to mutations in TSC1 or TSC2. Although various types of tumours occur in patients with this disorder, arguably the most important clinical issue is neurological disease, consisting of high risk of seizures, autism spectrum and other behavioural disorders, and intellectual disability.1 Two-thirds of infants with tuberous sclerosis complex develop epilepsy as infantile spasms or focal-onset disease.