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[Comment] Should blood pressure reduction be aggressive in patients with hypertension and coronary artery disease?

In The Lancet, Emmanuelle Vidal-Petiot and colleagues1 show that in patients with hypertension and stable coronary artery disease included in the multicountry CLARIFY registry, non-fatal and fatal outcomes decreased as blood pressure was reduced to a 120–139 mm Hg systolic or a 70–79 mm Hg diastolic range over 5 years of treatment. Blood pressure reductions to less than 120/70 mm Hg, however, were accompanied by a marked increase of cardiovascular risk that involved cause-specific events such as myocardial infarction and heart failure, only sparing stroke, whose risk remained similar to that seen at the higher blood pressure values.